Yeah, groupsex seems to be the way to go
Have you tried MO2? It makes modding a hell of a lot easier...Getting that itch to replay Fallout New Vegas again, but my god I don't feel like to mod it at all
It basically just stores all mods in a seperate folder, and creates a virtual folder with all mods included when you start your executable. I used it for my current Skyrim run, and it's the stablest I've ever gotten it, even with 300+ mods.
Or, you can just play it vanilla But then you might just as well install Unofficial Patch... And some texture packs... And maybe a mesh replacer... And maybe some extra armor parts... oh, and an overhaul for the casino's... Goddammit, you're 200 mods deep.